Open AccessInfluence of Apolipoprotein E ϵ4 Genotype on Brain Tissue Integrity in Relapsing-Remitting Multiple Sclerosis
Author(s) -
Nicola De Stefano,
Maria Letizia Bartolozzi,
Benedetta Nacmias,
Valentina Zipoli,
M. Mortilla,
Leonello Guidi,
G. Siracusa,
Sandro Sorbi,
Antonio Federico,
Maria Pia Amato
Publication year - 2004
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.61.4.536
Subject(s) - apolipoprotein e , multiple sclerosis , genotype , allele , medicine , magnetic resonance imaging , pathology , central nervous system disease , disease , gastroenterology , immunology , biology , radiology , genetics , gene
Recent clinical and imaging studies have raised the hypothesis that patients with multiple sclerosis (MS) and the apolipoprotein E (ApoE) epsilon4 allele may have a more severe disease course than those without the ApoE epsilon4 allele. This seems to be related to more extensive tissue destruction and less efficient neuronal maintenance and repair in ApoE epsilon4 carriers.