Open AccessThe Combined Effect of Paraoxonase Promoter and Coding Region Polymorphisms on the Risk of Arterial Ischemic Stroke Among Young Adults
Author(s) -
Barbara Voetsch,
Kelly S. Benke,
Carolien Panhuysen,
Alfredo Damasceno,
Joseph Loscalzo
Publication year - 2004
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.61.3.351
Subject(s) - pon1 , paraoxonase , odds ratio , allele , medicine , genotype , gastroenterology , confidence interval , pathogenesis , restriction fragment length polymorphism , endocrinology , genetics , biology , gene , oxidative stress
Serum paraoxonase (PON1) is a high-density lipoprotein-associated esterase with antioxidant and antiatherogenic properties that has recently been implicated in the pathogenesis of cardiovascular disease. Interindividual variability in PON1 levels is determined by the Q192R and L55M coding region polymorphisms and by 2 recently described polymorphisms in the promoter of the PON1 gene, C(-107)T and G(-824)A.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom