Open AccessWhen Sporadic Disease Is Not Sporadic
Author(s) -
Jill Goldman,
Bruce L. Miller,
Jiri Safar,
Sunita de Tourreil,
Jennifer L. Martindale,
Stanley B. Prusiner,
Michael D. Geschwind
Publication year - 2004
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.61.2.213
Subject(s) - family history , disease , medicine , etiology , presenilin , genetic testing , dementia , genetic counseling , medical history , pediatrics , alzheimer's disease , pathology , genetics , biology
Approximately 2% of Alzheimer disease cases and 10% to 15% of prion disease cases are due to mutations in autosomal dominant genes. Mutations have been found in patients without family histories of neurological disease.
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