The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis | Zendy

Maria Carmela Tartaglia | Zendy; Sridar Narayanan | Zendy; Simon J. Francis | Zendy; Antônio Carlos dos Santos | Zendy; Nicola De Stefano | Zendy; Yves Lapierre | Zendy; Douglas L. Arnold | Zendy

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The Relationship Between Diffuse Axonal Damage and Fatigue in Multiple Sclerosis

Author(s) -

Maria Carmela Tartaglia,

Sridar Narayanan,

Simon J. Francis,

Antônio Carlos dos Santos,

Nicola De Stefano,

Yves Lapierre,

Douglas L. Arnold

Publication year - 2004

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneur.61.2.201

Subject(s) - multiple sclerosis , medicine , magnetic resonance imaging , expanded disability status scale , creatine , lesion , cardiology , pathology , radiology , psychiatry

Fatigue is a common and distressing symptom for patients with multiple sclerosis (MS). There is growing evidence that fatigue in MS has a central nervous system component. We hypothesized that diffuse cerebral axonal damage could be associated with fatigue and used proton magnetic resonance spectroscopy to noninvasively measure axonal damage or loss in the brains of patients with MS.

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