Cortical Myoclonus During Lithium Exposure | Zendy

John N. Caviness | Zendy; Virgilio Gerald H. Evidente | Zendy

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Cortical Myoclonus During Lithium Exposure

Author(s) -

John N. Caviness,

Virgilio Gerald H. Evidente

Publication year - 2003

Publication title -

archives of neurology

Language(s) - English

Resource type - Journals

eISSN - 1538-3687

pISSN - 0003-9942

DOI - 10.1001/archneur.60.3.401

Subject(s) - myoclonus , anesthesia , electroencephalography , medicine , somatosensory evoked potential , clinical neurophysiology , lithium (medication) , electromyography , psychology , neuroscience

Myoclonus can occur in association with lithium therapy at toxic and therapeutic dosages, and can be a predominant and disabling adverse effect. Moreover, myoclonus has been reported when lithium has been combined with cyclic antidepressants and with the neuroleptic clozapine. Although clinical case reports exist, no electrophysiologic data are available that provide a source or a neurophysiological mechanism for the myoclonus seen in lithium therapy.

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