Open AccessHigh-Dose Methylprednisolone Therapy in Multiple Sclerosis Induces Apoptosis in Peripheral Blood Leukocytes
Author(s) -
Verena I. Leussink,
Stefan Jung,
Ursula Merschdorf,
Klaus V. Toyka,
Ralf Gold
Publication year - 2001
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.58.1.91
Subject(s) - apoptosis , tunel assay , medicine , immunology , methylprednisolone , peripheral blood mononuclear cell , endocrinology , biology , in vitro , immunohistochemistry , biochemistry
Apoptosis is supposed to contribute to the elimination of T cells from the inflamed central nervous system in the natural disease course of multiple sclerosis (MS). In the animal model experimental autoimmune encephalomyelitis, T-cell apoptosis can be induced by high-dose glucocorticoid (GC) administration.
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