Open AccessAxonal Injury or Loss in the Internal Capsule and Motor Impairment in Multiple Sclerosis
Author(s) -
Martin A. Lee,
Andrew M. Blamire,
Sarah T. Pendlebury,
King-Hee Ho,
Kerry Mills,
Peter Styles,
Jackie Palace,
Paul M. Matthews
Publication year - 2000
Publication title -
archives of neurology
Language(s) - English
Resource type - Journals
eISSN - 1538-3687
pISSN - 0003-9942
DOI - 10.1001/archneur.57.1.65
Subject(s) - internal capsule , white matter , multiple sclerosis , motor function , motor impairment , medicine , magnetic resonance imaging , anatomy , cardiology , physical medicine and rehabilitation , radiology , psychiatry
To test the hypothesis that axonal damage extending into primarily normal-appearing white matter is clinically important by comparing the concentrations of N-acetylaspartate (NAA) bilaterally within the internal capsule with lateralization of motor impairment in patients with multiple sclerosis (MS) and persistent asymmetrical motor deficit.
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