Open AccessOpioid Dose and Drug-Related Mortality in Patients With Nonmalignant Pain
Author(s) -
Tara Gomes,
Muhammad Mamdani,
Irfan A. Dhalla,
J. Michael Paterson,
David N. Juurlink
Publication year - 2011
Publication title -
archives of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 1538-3679
pISSN - 0003-9926
DOI - 10.1001/archinternmed.2011.117
Subject(s) - medicine , opioid , morphine , odds ratio , confidence interval , population , medical prescription , anesthesia , pharmacology , receptor , environmental health
Opioids are widely prescribed for chronic nonmalignant pain, often at doses exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of high-dose opioid therapy is not well characterized. The objective of this study was to characterize the relationship between opioid dose and opioid-related mortality.
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