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Metformin is recommended in type 2 diabetes mellitus because it reduced mortality among overweight participants in the United Kingdom Prospective Diabetes Study when used mainly as a means of primary prevention. However, metformin is often not considered in patients with cardiovascular conditions because of concerns about its safety.

archives of internal medicine

Metformin Use and Mortality Among Patients With Diabetes and Atherothrombosis&lt;alt-title&gt;Metformin Use With Diabetes and Atherothrombosis&lt;/alt-title&gt;