Hemorrhage During Warfarin Therapy Associated With Cotrimoxazole and Other Urinary Tract Anti-infective Agents | Zendy

Hadas D. Fischer | Zendy; David N. Juurlink | Zendy; Muhammad Mamdani | Zendy; Alexander Kopp | Zendy; Andreas Laupacis | Zendy

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Hemorrhage During Warfarin Therapy Associated With Cotrimoxazole and Other Urinary Tract Anti-infective Agents

Author(s) -

Hadas D. Fischer,

David N. Juurlink,

Muhammad Mamdani,

Alexander Kopp,

Andreas Laupacis

Publication year - 2010

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinternmed.2010.37

Subject(s) - medicine , nitrofurantoin , warfarin , amoxicillin , odds ratio , ampicillin , ciprofloxacin , population , antibacterial agent , urinary system , surgery , antibiotics , gastroenterology , environmental health , microbiology and biotechnology , biology , atrial fibrillation

Some antibiotic agents, including cotrimoxazole, inhibit the metabolism of warfarin sodium and possibly increase the risk of hemorrhage. We examined the risk of upper gastrointestinal (UGI) tract hemorrhage in older patients receiving warfarin in combination with antibiotics commonly used to treat urinary tract infection, with a focus on cotrimoxazole.

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