Optimal Level of Oral Anticoagulant Therapy for the Prevention of Arterial Thrombosis in Patients With Mechanical Heart Valve Prostheses, Atrial Fibrillation, or Myocardial Infarction | Zendy

Marieke Torn | Zendy; Suzanne C. Cannegieter | Zendy; Ward L. E. M. Bollen | Zendy; F.J.M. van der Meer | Zendy; Ernst E. van der Wall | Zendy; Frits R. Rosendaal | Zendy

Open Access

Optimal Level of Oral Anticoagulant Therapy for the Prevention of Arterial Thrombosis in Patients With Mechanical Heart Valve Prostheses, Atrial Fibrillation, or Myocardial Infarction

Author(s) -

Marieke Torn,

Suzanne C. Cannegieter,

Ward L. E. M. Bollen,

F.J.M. van der Meer,

Ernst E. van der Wall,

Frits R. Rosendaal

Publication year - 2009

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinternmed.2009.176

Subject(s) - medicine , atrial fibrillation , myocardial infarction , cardiology , incidence (geometry) , thrombosis , anticoagulant , stroke (engine) , anticoagulant therapy , mechanical engineering , physics , optics , engineering

Oral anticoagulant therapy is effective for the prevention of arterial thromboembolism in various patient groups. The increased risk of hemorrhage remains the major drawback to this therapy and is associated with the intensity of anticoagulation. Finding the optimal intensity at which the overall incidence rate of both bleeding and thromboembolic events is minimized represents a way to improve the safety of oral anticoagulant treatment.

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