Albuminuria and Renal Function in Homozygous Sickle Cell Disease | Zendy

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Albuminuria and Renal Function in Homozygous Sickle Cell Disease

Author(s) -

Joanne Thompson

Publication year - 2007

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.167.7.701

Subject(s) - renal function , albuminuria , creatinine , medicine , endocrinology , kidney disease , excretion , blood pressure , hematocrit , effective renal plasma flow , urinary system , renal blood flow , urology

The glomerular filtration rate (GFR) in homozygous sickle cell (SS) disease is supranormal in childhood but falls steeply with age, often culminating in renal failure. The risk factors underlying these observations are unclear. We therefore sought to investigate the relationships between blood pressure, renal hemodynamics, and urinary albumin excretion in subjects with SS disease and matched controls with a normal AA genotype (hereinafter, controls) as a prelude to intervention studies.

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