Open AccessRisk of Osteoporotic Fracture in Elderly Patients Taking Warfarin
Author(s) -
Brian F. Gage,
Elena Birman-Deych,
Martha J. Radford,
David S. Nilasena,
Ellen F. Binder
Publication year - 2006
Publication title -
archives of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 1538-3679
pISSN - 0003-9926
DOI - 10.1001/archinte.166.2.241
Subject(s) - warfarin , medicine , atrial fibrillation , odds ratio , osteoporosis , confidence interval , retrospective cohort study
Vitamin K allows for gamma-carboxylation of glutamyl residues, a conversion that activates clotting factors and bone proteins. Vitamin K antagonists such as warfarin inhibit this process. Our goal was to quantify the association between warfarin and osteoporotic fractures in patients with atrial fibrillation.
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