The Effects of Cyclooxygenase-2 Inhibitors and Nonsteroidal Anti-inflammatory Therapy on 24-Hour Blood Pressure in Patients With Hypertension, Osteoarthritis, and Type 2 Diabetes Mellitus | Zendy

James R. Sowers | Zendy; William B. White | Zendy; Bertram Pitt | Zendy; Andrew Whelton | Zendy; Lee S. Simon | Zendy; Nathaniel Winer | Zendy; Alan Kivitz | Zendy; Hein van Ingen | Zendy; Thomas Brabant | Zendy; John G. Fort | Zendy

Open Access

The Effects of Cyclooxygenase-2 Inhibitors and Nonsteroidal Anti-inflammatory Therapy on 24-Hour Blood Pressure in Patients With Hypertension, Osteoarthritis, and Type 2 Diabetes Mellitus

Author(s) -

James R. Sowers,

William B. White,

Bertram Pitt,

Andrew Whelton,

Lee S. Simon,

Nathaniel Winer,

Alan Kivitz,

Hein van Ingen,

Thomas Brabant,

John G. Fort

Publication year - 2005

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.165.2.161

Subject(s) - rofecoxib , medicine , celecoxib , naproxen , osteoarthritis , blood pressure , cyclooxygenase , arthritis , anesthesia , gastroenterology , biochemistry , chemistry , alternative medicine , pathology , enzyme

Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors may attenuate the efficacy of antihypertensive agents in high-risk patients. Therefore, we conducted a double-blind, randomized trial to evaluate the effects of celecoxib, rofecoxib, and naproxen on 24-hour blood pressure (BP) in patients with type 2 diabetes, hypertension, and osteoarthritis.

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