Open AccessAssociation of Risk of Abnormal Bleeding With Degree of Serotonin Reuptake Inhibition by Antidepressants
Author(s) -
Welmoed E. E. Meijer,
Eibert R. Heerdink,
Willem A. Nolen,
Ron M. C. Herings,
Hubert G. M. Leufkens,
Toine C. G. Egberts
Publication year - 2004
Publication title -
archives of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 1538-3679
pISSN - 0003-9926
DOI - 10.1001/archinte.164.21.2367
Subject(s) - odds ratio , reuptake inhibitor , antidepressant , serotonin reuptake inhibitor , medicine , confidence interval , serotonin , receptor , hippocampus
Serotonin plays a role in platelet aggregation. Because antidepressants influence blood serotonin levels, their use may be associated with an increased risk of abnormal bleeding. However, previous studies were inconclusive regarding this association. The aim of this study was to estimate the risk of abnormal bleeding associated with the use of antidepressants and to establish the relationship between serotonin reuptake inhibition and the risk of bleeding.
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