Use of a Fixed Activated Partial Thromboplastin Time Ratio to Establish a Therapeutic Range for Unfractionated Heparin | Zendy

Shan M. Bates | Zendy; Jeffrey I. Weitz | Zendy; Marilyn Johnston | Zendy; Jack Hirsh | Zendy; Jeffrey S. Ginsberg | Zendy

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Use of a Fixed Activated Partial Thromboplastin Time Ratio to Establish a Therapeutic Range for Unfractionated Heparin

Author(s) -

Shan M. Bates,

Jeffrey I. Weitz,

Marilyn Johnston,

Jack Hirsh,

Jeffrey S. Ginsberg

Publication year - 2001

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.161.3.385

Subject(s) - partial thromboplastin time , heparin , therapeutic index , prothrombin time , reagent , medicine , coagulation , chemistry , pharmacology , surgery , drug

The commonly recommended therapeutic range for patients receiving unfractionated heparin of 1.5 to 2.5 times the control activated partial thromboplastin time (aPTT) is not universally applicable. It has been suggested that the therapeutic range for each aPTT reagent should be based on plasma heparin levels. We sought to identify an aPTT ratio that corresponds to therapeutic anti--factor Xa heparin levels for combinations of several reagents and coagulometers that are commonly used.

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