Open AccessIncreased Plasma Methylmalonic Acid Level Does Not Predict Clinical Manifestations of Vitamin B12 Deficiency
Author(s) -
AnneMette Hvas,
Jørgen Ellegaard,
Ebba Nexø
Publication year - 2001
Publication title -
archives of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 1538-3679
pISSN - 0003-9926
DOI - 10.1001/archinte.161.12.1534
Subject(s) - methylmalonic acid , vitamin b12 , medicine , homocysteine , vitamin b , coefficient of variation , vitamin , gastroenterology , folic acid , endocrinology , chemistry , chromatography
The prevalence of vitamin B(12) deficiency, defined as an elevated concentration of plasma methylmalonic acid (P-MMA), has been estimated to be 15% to 44% in the elderly. However, we do not know whether an increased P-MMA level actually indicates or predicts a clinical condition in need of treatment.
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