Unresolved Issues in the Role of Cyclooxygenase-2 in Normal Physiologic Processes and Disease | Zendy

Peter E. Lipsky | Zendy; Peter C. Brooks | Zendy; Leslie J. Crofford | Zendy; Raymond N. DuBois | Zendy; David Graham | Zendy; Lee S. Simon | Zendy; Leo B. A. Van De Putte | Zendy; Steven B. Abramson | Zendy

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Unresolved Issues in the Role of Cyclooxygenase-2 in Normal Physiologic Processes and Disease

Author(s) -

Peter E. Lipsky,

Peter C. Brooks,

Leslie J. Crofford,

Raymond N. DuBois,

David Graham,

Lee S. Simon,

Leo B. A. Van De Putte,

Steven B. Abramson

Publication year - 2000

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.160.7.913

Subject(s) - cyclooxygenase , antithrombotic , disease , function (biology) , medicine , intensive care medicine , neuroscience , pharmacology , bioinformatics , biology , enzyme , microbiology and biotechnology , biochemistry

Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.

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