A Randomized Trial Comparing 5-mg and 10-mg Warfarin Loading Doses | Zendy

Mark Crowther | Zendy; Jeff Ginsberg | Zendy; Clive Kearon | Zendy; Linda Harrison | Zendy; Jian H. Johnson | Zendy; M. Patricia Massicotte | Zendy; Jack Hirsh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Randomized Trial Comparing 5-mg and 10-mg Warfarin Loading Doses

Author(s) -

Mark Crowther,

Jeff Ginsberg,

Clive Kearon,

Linda Harrison,

Jian H. Johnson,

M. Patricia Massicotte,

Jack Hirsh

Publication year - 1999

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.159.1.46

Subject(s) - warfarin , medicine , dosing , warfarin sodium , confidence interval , loading dose , maintenance dose , randomized controlled trial , therapeutic index , clinical endpoint , anesthesia , pharmacology , atrial fibrillation , drug

Warfarin sodium therapy is usually initiated with a loading dose to reduce the time required to elevate the international normalized ratio (INR). Warfarin loading doses are associated with early overanticoagulation and the development of a potential hypercoagulable state; they also may not hasten achieving an INR value between 2.0 and 3.0. This study was designed to prospectively confirm our observation that a 5-mg warfarin sodium loading dose is as effective as a 10-mg loading dose in achieving a therapeutic INR for 2 consecutive days on days 3 and 4 or 4 and 5 of therapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research