A Randomized Controlled Trial Comparing Zileuton With Theophylline in Moderate Asthma | Zendy

Howard J. Schwartz | Zendy; Thomas L. Petty | Zendy; Louise M. Dubé | Zendy; Linda J. Swanson | Zendy; John F. Lancaster | Zendy

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A Randomized Controlled Trial Comparing Zileuton With Theophylline in Moderate Asthma

Author(s) -

Howard J. Schwartz,

Thomas L. Petty,

Louise M. Dubé,

Linda J. Swanson,

John F. Lancaster

Publication year - 1998

Publication title -

archives of internal medicine

Language(s) - English

Resource type - Journals

eISSN - 1538-3679

pISSN - 0003-9926

DOI - 10.1001/archinte.158.2.141

Subject(s) - zileuton , medicine , theophylline , asthma , placebo , anesthesia , bronchodilator , spirometry , crossover study , randomized controlled trial , arachidonic acid , arachidonate 5 lipoxygenase , chemistry , biochemistry , alternative medicine , pathology , enzyme

Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double-blind study of patients with chronic asthma. The primary efficacy measure was improvement in forced expiratory volume in 1 second (FEV1).

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