Open AccessAssociation Between Common Variants Near the Melanocortin 4 Receptor Gene and Severe Antipsychotic Drug–Induced Weight Gain
Author(s) -
Anil K. Malhotra,
Christoph U. Correll,
Nabilah I. Chowdhury,
Daniel J. Müller,
Peter K. Gregersen,
Annette T. Lee,
Arun K. Tiwari,
John M. Kane,
W. Wolfgang Fleischhacker,
René S. Kahn,
Roel A. Ophoff,
Jeffrey A. Lieberman,
Herbert Y. Meltzer,
Todd Lencz,
James L. Kennedy
Publication year - 2012
Publication title -
archives of general psychiatry
Language(s) - English
Resource type - Journals
eISSN - 1538-3636
pISSN - 0003-990X
DOI - 10.1001/archgenpsychiatry.2012.191
Subject(s) - antipsychotic , genome wide association study , medicine , weight gain , cohort , single nucleotide polymorphism , pharmacogenetics , major depressive disorder , population , genetic association , oncology , psychiatry , genetics , schizophrenia (object oriented programming) , genotype , biology , gene , body weight , environmental health , amygdala
Second-generation antipsychotics (SGAs) are increasingly used in the treatment of many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk.