The IgG “Lupus-Band” Deposition Pattern of Pemphigus Erythematosus | Zendy

Dyah Ayu Mira Oktarina | Zendy; Angelique Poot | Zendy; Duco Kramer | Zendy; Gilles F.H. Diercks | Zendy; Marcel F. Jonkman | Zendy; Hendri H. Pas | Zendy

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The IgG “Lupus-Band” Deposition Pattern of Pemphigus Erythematosus

Author(s) -

Dyah Ayu Mira Oktarina,

Angelique Poot,

Duco Kramer,

Gilles F.H. Diercks,

Marcel F. Jonkman,

Hendri H. Pas

Publication year - 2012

Publication title -

archives of dermatology

Language(s) - English

Resource type - Journals

eISSN - 1538-3652

pISSN - 0003-987X

DOI - 10.1001/archdermatol.2012.1896

Subject(s) - pemphigus foliaceus , desmoglein 1 , pemphigus , medicine , basement membrane , lamina densa , lupus erythematosus , dermatology , antibody , autoimmune disease , pathology , immunology , autoantibody

Pemphigus foliaceus is an autoimmune skin disease characterized by subcorneal blistering and IgG antibodies directed against desmoglein 1. In the skin, these antibodies deposit intraepidermally. On rare occasions,an additional “lupus band” of granular depositions of IgG and complement is seen along the epidermal basement membrane zone. This combined pattern has been connected with a variant of pemphigus foliaceus named pemphigus erythematosus.

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