Pyoderma Gangrenosum–Like Ulcer in a Patient With X-Linked Agammaglobulinemia | Zendy

Patrick R. Murray | Zendy; Ashish Jain | Zendy; Gülbû Uzel | Zendy; Raymond Ranken | Zendy; Cristina Ivy | Zendy; Lawrence B. Blyn | Zendy; David J. Ecker | Zendy; Rangarajan Sampath | Zendy; ChyiChia Richard Lee | Zendy; Maria L. Turner | Zendy

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Pyoderma Gangrenosum–Like Ulcer in a Patient With X-Linked Agammaglobulinemia

Author(s) -

Patrick R. Murray,

Ashish Jain,

Gülbû Uzel,

Raymond Ranken,

Cristina Ivy,

Lawrence B. Blyn,

David J. Ecker,

Rangarajan Sampath,

ChyiChia Richard Lee,

Maria L. Turner

Publication year - 2010

Publication title -

archives of dermatology

Language(s) - English

Resource type - Journals

eISSN - 1538-3652

pISSN - 0003-987X

DOI - 10.1001/archdermatol.2010.86

Subject(s) - pyoderma gangrenosum , medicine , dermatology , pyoderma , x linked agammaglobulinemia , disease , receptor , tyrosine kinase , bruton's tyrosine kinase

Pyoderma gangrenosum-like ulcers and cellulitis of the lower extremities associated with recurrent fevers in patients with X-linked (Bruton) agammaglobulinemia have been reported to be caused by Helicobacter bilis (formerly classified as Flexispira rappini and then Helicobacter strain flexispira taxon 8). Consistent themes in these reports are the difficulty in recovering this organism in blood and wound cultures and in maintaining isolates in vitro. We confirmed the presence of this organism in a patient's culture by using a novel application of gene amplification polymerase chain reaction and electrospray ionization time-of-flight mass spectrometry.

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