Adverse Events Following Smallpox Vaccination With ACAM2000 in a Military Population | Zendy

Thomas M. Beachkofsky | Zendy; Scott C. Carrizales | Zendy; Jeffrey J. Bidinger | Zendy; David Hrncir | Zendy; Darren E. Whittemore | Zendy; Chad Hivnor | Zendy

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Adverse Events Following Smallpox Vaccination With ACAM2000 in a Military Population

Author(s) -

Thomas M. Beachkofsky,

Scott C. Carrizales,

Jeffrey J. Bidinger,

David Hrncir,

Darren E. Whittemore,

Chad Hivnor

Publication year - 2010

Publication title -

archives of dermatology

Language(s) - English

Resource type - Journals

eISSN - 1538-3652

pISSN - 0003-987X

DOI - 10.1001/archdermatol.2010.46

Subject(s) - medicine , smallpox , vaccinia , vaccination , dermatology , smallpox vaccine , population , incidence (geometry) , immunization , immunology , virology , antibody , biochemistry , chemistry , environmental health , gene , recombinant dna , physics , optics

Generalized vaccinia and benign exanthems are 2 adverse events that have been associated with the smallpox vaccination. Accurate incidence and prevalence rates of each are not readily available, but these events are thought to be uncommon. To our knowledge, this is the first case series to provide clinical as well as pathologic descriptions of multiple papulovesicular eruptions occurring after receiving the second-generation smallpox vaccine, ACAM2000 (Acambis, Canton, Massachusetts), among a vaccinia-naïve military population. In addition, we report the first confirmed case, to our knowledge, of generalized vaccinia following administration of the ACAM2000 vaccine.

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