Diltiazem Induces Severe Photodistributed Hyperpigmentation | Zendy

Rao N. Saladi | Zendy; Steven R. Cohen | Zendy; Robert Phelps | Zendy; Andrea N. Persaud | Zendy; Donald Rudikoff | Zendy

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Diltiazem Induces Severe Photodistributed Hyperpigmentation

Author(s) -

Rao N. Saladi,

Steven R. Cohen,

Robert Phelps,

Andrea N. Persaud,

Donald Rudikoff

Publication year - 2006

Publication title -

archives of dermatology

Language(s) - English

Resource type - Journals

eISSN - 1538-3652

pISSN - 0003-987X

DOI - 10.1001/archderm.142.2.206

Subject(s) - diltiazem , medicine , hyperpigmentation , dermatology , biopsy , skin biopsy , pathology , anti nuclear antibody , antibody , autoantibody , immunology , alternative medicine

Diltiazem hydrochloride is a commonly prescribed benzothiazepine calcium channel blocker for the treatment of cardiovascular disease. Recently, 8 cases of diltiazem-induced photodistributed hyperpigmentation occurring predominantly in elderly African American women were reported. Here, we report occurrence for the first time in a light-skinned African American woman and a Hispanic woman. We also report this finding in an African American man. Biopsy specimens of hyperpigmented areas were obtained for histopathologic evaluation and marker studies. Photospectrometry analysis for diltiazem was performed to analyze the photoabsorption properties of this drug.

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