Open AccessLow Prevalence of Germline CDKN2A and CDK4 Mutations in Patients With Early-Onset Melanoma
Author(s) -
Hensin Tsao,
Xue Zhang,
Kimberly Kwitkiwski,
Dianne M. Finkelstein,
Arthur J. Sober,
Frank G. Haluska
Publication year - 2000
Publication title -
archives of dermatology
Language(s) - English
Resource type - Journals
eISSN - 1538-3652
pISSN - 0003-987X
DOI - 10.1001/archderm.136.9.1118
Subject(s) - cdkn2a , medicine , melanoma , germline mutation , germline , exon , confidence interval , oncology , gastroenterology , mutation , cancer , cancer research , genetics , gene , biology
In patients with cutaneous melanoma, early age at disease onset is characteristic in familial cases and in individuals with multiple primary melanomas. Both subsets of patients with melanoma are at risk for harboring germline CDKN2A or CDK4 mutations.
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