Expression of p53 in Arsenic-Related and Sporadic Basal Cell Carcinoma | Zendy

Waranya Boonchai | Zendy; Michael D. Walsh | Zendy; Margaret C. Cummings | Zendy; Georgia ChenevixTrench | Zendy

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Expression of p53 in Arsenic-Related and Sporadic Basal Cell Carcinoma

Author(s) -

Waranya Boonchai,

Michael D. Walsh,

Margaret C. Cummings,

Georgia ChenevixTrench

Publication year - 2000

Publication title -

archives of dermatology

Language(s) - English

Resource type - Journals

eISSN - 1538-3652

pISSN - 0003-987X

DOI - 10.1001/archderm.136.2.195

Subject(s) - basal cell carcinoma , arsenic , medicine , methylation , cancer research , gene silencing , dna methylation , gene , immunohistochemistry , cancer , gene expression , pathology , biology , basal cell , genetics , chemistry , organic chemistry

The TP53 gene has been shown to have an important role in the genesis of sporadic, presumably mainly sunlight-related, basal cell carcinoma (BCC). However, its role in arsenic-related BCCs is not clear, although the trivalent form of arsenic has been long recognized as a cause of BCC. Arsenic treatment has been shown to cause hypermethylation of the TP53 gene in lung carcinoma cell lines, but it is not known if this occurs in vivo in arsenic-related BCCs.

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