Open AccessSevere Hypersensitivity Syndrome Due to Sulfasalazine Associated With Reactivation of Human Herpesvirus 6
Author(s) -
Mikiko Tohyama,
Yoko Yahata,
Masaki Yasukawa,
Reiko Inagi,
Yoshio Urano,
Koichi Yamanishi,
Koji Hashimoto
Publication year - 1998
Publication title -
archives of dermatology
Language(s) - English
Resource type - Journals
eISSN - 1538-3652
pISSN - 0003-987X
DOI - 10.1001/archderm.134.9.1113
Subject(s) - medicine , sulfasalazine , human herpesvirus 6 , leukocytosis , maculopapular rash , rash , immunology , mononucleosis , hypersensitivity reaction , dermatology , herpesviridae , pathology , virus , viral disease , disease , ulcerative colitis
A severe adverse reaction to sulfasalazine therapy has been associated with hypersensitivity syndrome, the clinical features of which are similar to infectious mononucleosis. No serologic evidence of viral infections has been reported with this syndrome; however, human herpesvirus 6 infection has not been specifically investigated, which could cause an infectious mononucleosislike syndrome.
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