The Pathophysiological Significance of Nondesmoglein Targets of Pemphigus Autoimmunity
Author(s) -
Vu Thuong Nguyen,
Tou X. Lee,
Assane Ndoye,
Leonard D. Shultz,
Mark R. Pittelkow,
Mark V. Dahl,
Peter Lynch,
Sergei A. Grando
Publication year - 1998
Publication title -
archives of dermatology
Language(s) - English
Resource type - Journals
eISSN - 1538-3652
pISSN - 0003-987X
DOI - 10.1001/archderm.134.8.971
Subject(s) - pemphigus vulgaris , medicine , pemphigus , pemphigus foliaceus , acantholysis , autoantibody , immunology , desmoglein 3 , autoimmunity , desmoglein , bullous pemphigoid , dermatology , immune system , antibody
To determine whether nondesmoglein (non-Dsg) autoantibodies are pathogenic and whether they recognize keratinocyte cholinergic receptors that control cell adhesion because antikeratinocyte autoimmunity in patients with pemphigus vulgaris is not limited to the development of autoantibodies to Dsg.
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