Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents With Major Depressive Disorder | Zendy

Paul E. Croarkin | Zendy; Paul A. Nakonezny | Zendy; Mustafa M. Husain | Zendy; Tabatha Melton | Zendy; Jeylan S. Buyukdura | Zendy; Betsy D. Kennard | Zendy; Graham J. Emslie | Zendy; F. Andrew Kozel | Zendy; Zafiris J. Daskalakis | Zendy

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Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents With Major Depressive Disorder

Author(s) -

Paul E. Croarkin,

Paul A. Nakonezny,

Mustafa M. Husain,

Tabatha Melton,

Jeylan S. Buyukdura,

Betsy D. Kennard,

Graham J. Emslie,

F. Andrew Kozel,

Zafiris J. Daskalakis

Publication year - 2013

Publication title -

jama psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.531

H-Index - 365

eISSN - 2168-6238

pISSN - 2168-622X

DOI - 10.1001/2013.jamapsychiatry.24

Subject(s) - transcranial magnetic stimulation , silent period , major depressive disorder , glutamatergic , psychology , facilitation , neuroscience , glutamate receptor , psychiatry , audiology , medicine , stimulation , cognition , receptor

Converging lines of evidence implicate the glutamate and γ-aminobutyric acid neurotransmitter systems in the pathophysiology of major depressive disorder. Transcranial magnetic stimulation cortical excitability and inhibition paradigms have been used to assess cortical glutamatergic and γ-aminobutyric acid-mediated tone in adults with major depressive disorder, but not in children and adolescents.

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