Serological Analysis of Alpha-synuclein and NF- κ B in Parkinson’s Disease Patients

Several investigations have been made to determine the level of alpha-synuclein in the peripheral blood of Parkinson's disease patients, but the results were very contradictory and inconclusive. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was also found to be involved in Parkinson's disease, but there is a lack of studies investigating NF-κB in Parkinson's disease patients. As far as our knowledge goes, no study reported the level of NF-κB in serum of Parkinson's disease patients. In this context, present study was designed to make a baseline study in order to evaluate the levels of total alpha-synuclein and NF-κB in serum of Parkinson's disease patients.