Open AccessSerological Analysis of Alpha-synuclein and NF- κ B in Parkinson’s Disease Patients
Author(s) -
Vishal Gupta,
Garg Rk,
Sanjay Khattri
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/12545.5978
Subject(s) - parkinson's disease , alpha synuclein , disease , medicine , context (archaeology) , gastroenterology , alpha (finance) , endocrinology , biology , surgery , patient satisfaction , paleontology , construct validity
Several investigations have been made to determine the level of alpha-synuclein in the peripheral blood of Parkinson's disease patients, but the results were very contradictory and inconclusive. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was also found to be involved in Parkinson's disease, but there is a lack of studies investigating NF-κB in Parkinson's disease patients. As far as our knowledge goes, no study reported the level of NF-κB in serum of Parkinson's disease patients. In this context, present study was designed to make a baseline study in order to evaluate the levels of total alpha-synuclein and NF-κB in serum of Parkinson's disease patients.