Open AccessNon Viral Vectors in Gene Therapy- An Overview
Author(s) -
Murali Ramamoorth,
Aparrvekar
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/10443.5394
Subject(s) - gene transfer , genetic enhancement , viral vector , bench to bedside , gene delivery , computational biology , computer science , vector (molecular biology) , nanotechnology , biology , gene , medicine , recombinant dna , materials science , genetics , medical physics
Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and extracellular barriers, number of other challenges also needs to be overcome in order to increase the effectiveness of non-viral gene transfer. These barriers are categorized as production, formulation and storage. No one-size-fits-all solution to gene delivery, which is why in spite of various developments in liposome, polymer formulation and optimization, new compounds are constantly being proposed and investigated. In this review, we will see in detail about various types of non-viral vectors highlighting promising development and recent advances that had improved the non-viral gene transfer efficiency of translating from "Bench to bedside".