Open AccessEvaluation of the antigenic stability of influenza virus like particles after exposure to acidic or basic pH
Author(s) -
So Hwa Kim,
Young Chan Park,
Jae Min Song
Publication year - 2021
Publication title -
clinical and experimental vaccine research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 11
eISSN - 2287-366X
pISSN - 2287-3651
DOI - 10.7774/cevr.2021.10.3.252
Subject(s) - antigenicity , antigen , chemistry , hemagglutination assay , virus , virology , immune system , in vivo , microbiology and biotechnology , influenza a virus , in vitro , biology , biochemistry , immunology , titer
Virus-like particles (VLPs) are being developed as a promising vaccine platform and therapeutic delivery. Various strategies for effectively constructing VLPs have been studied, but relatively few studies have been done on various factors affecting storage. In this study, we investigated the antigenic changes of VLPs in an acidic or basic pH environment using influenza VLPs as an experimental model.