Open AccessOral immunization of rat with chromosomal expression LipL32 in attenuated Salmonella vaccine induces immune respond against pathogenic Leptospira
Author(s) -
Natthapon Samakchan,
Patipat Thinwang,
Rerngwit Boonyom
Publication year - 2021
Publication title -
clinical and experimental vaccine research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.958
H-Index - 11
eISSN - 2287-366X
pISSN - 2287-3651
DOI - 10.7774/cevr.2021.10.3.217
Subject(s) - leptospira , immune system , antibody , vaccination , dna vaccination , immunization , microbiology and biotechnology , biology , salmonella , antigen , virology , secretion , immunity , leptospirosis , immunology , bacteria , genetics , biochemistry
Leptospirosis caused by Leptospira spp. remains a global health problem. Available commercial leptospiral vaccines have shown an ineffective prevention for leptospiral infection. The aim of this study was to develop leptospirosis vaccine using recombinant attenuated Salmonella vaccine (RASV) as a platform. We expected that this vaccine has ability to continuous and strongly stimulate immune systems including protective mucosal, humoral, and cell mediated immunity in rat model.