Open AccessClinical management of primary odontogenic sarcoma in the mandible: a case report after WHO nomination
Author(s) -
Quing Zhu,
Chenxing Wang,
Yizhou Wang,
Songsong Guo,
Jinhai Ye
Publication year - 2022
Publication title -
journal of biomedical research/journal of biomedical research
Language(s) - English
Resource type - Journals
eISSN - 2352-4685
pISSN - 1674-8301
DOI - 10.7555/jbr.35.20210133
Subject(s) - medicine , mandible (arthropod mouthpart) , sarcoma , odontogenic , metastasis , distant metastasis , adjuvant therapy , pathology , surgery , cancer , biology , chemotherapy , botany , genus
Ameloblastic fibro-odontosarcoma (AFOS) now designated as odontogenic sarcoma is an extremely rare odontogenic tumor, which histologically presents as a biphasic neoplasm with a malignant mesenchymal component plus ameloblastic epithelium. Here we report a 27-year-old Chinese female with the complaint of a painful swelling for half a month in the right mandible. A segmental mandibulectomy, with an immediate mandibular reconstruction using a free vascularized osteocutaneous fibular flap was performed using surgical guide models. Histological analysis revealed a primary odontogenic sarcoma. The postoperative period was uneventful, and no clinical indication of recurrence or metastasis was observed during the 3-year follow-up. No adjuvant therapy was proposed. This is the first odontogenic sarcoma case reported in China after the new World Health Organization classification of odontogenic lesions.