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Animals have evolved unique repertoires of innate immune genes and pathways that provide their first line of defense against pathogens. To reconstruct the ancestry of animal innate immunity, we have developed the choanoflagellate  Monosiga brevicollis , one of the closest living relatives of animals, as a model for studying mechanisms underlying pathogen recognition and immune response. We found that  M. brevicollis  is killed by exposure to  Pseudomonas aeruginosa  bacteria. Moreover,  M. brevicollis  expresses STING, which, in animals, activates innate immune pathways in response to cyclic dinucleotides during pathogen sensing.  M. brevicollis  STING increases the susceptibility of  M. brevicollis  to  P. aeruginosa -induced cell death and is required for responding to the cyclic dinucleotide 2’3’ cGAMP. Furthermore, similar to animals, autophagic signaling in  M. brevicollis  is induced by 2’3’ cGAMP in a STING-dependent manner. This study provides evidence for a pre-animal role for STING in antibacterial immunity and establishes  M. brevicollis  as a model system for the study of immune responses.

STING mediates immune responses in the closest living relatives of animals