open-access-imgOpen AccessScreening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
Rivett Lucy,
Sridhar Sushmita,
Sparkes Dominic,
Routledge Matthew,
Jones Nick K,
Forrest Sally,
Young Jamie,
Pereira-Dias Joana,
Hamilton William L,
Ferris Mark,
Torok M Estee,
Meredith Luke,
Curran Martin D,
Fuller Stewart,
Chaudhry Afzal,
Shaw Ashley,
Samworth Richard J,
Bradley John R,
Dougan Gordon,
Smith Kenneth GC,
Lehner Paul J,
Matheson Nicholas J,
Wright Giles,
Goodfellow Ian G,
Baker Stephen,
Weekes Michael P
Publication year2020
Publication title
Resource typeJournals
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff.
Subject(s)research article
Keyword(s) COVID-19 , SARS-CoV-2 , infectious disease , virology , occupational health , emerging pathogens
SCImago Journal Rank5.879

Seeing content that should not be on Zendy? Contact us.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here