English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Klebsiella pneumoniae  is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection against  K. pneumoniae  (ATCC 43816) pulmonary infections.  Skap2-/ - mice had 100-fold higher bacterial burden when compared to wild-type and burden was controlled by SKAP2 expression in innate immune cells.  Skap2-/ - neutrophils and monocytes were present in infected lungs, and the neutrophils degranulated normally in response to  K. pneumoniae  infection in mice; however,  K. pneumoniae -stimulated reactive oxygen species (ROS) production in vitro was abolished.  K. pneumoniae -induced neutrophil ROS response required the activity of SFKs, Syk, Btk, PLCγ2, and PKC. The loss of SKAP2 significantly hindered the  K. pneumoniae -induced phosphorylation of SFKs, Syk, and Pyk2 implicating SKAP2 as proximal to their activation in pathogen-signaling pathways. In conclusion, SKAP2-dependent signaling in neutrophils is essential for  K. pneumoniae -activated ROS production and for promoting bacterial clearance during infection.

SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst