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Because chromatin determines whether information encoded in DNA is accessible to transcription factors, dynamic chromatin states in development may constrain how gene regulatory networks impart embryonic pattern. To determine the interplay between chromatin states and regulatory network function, we performed ATAC-seq on  Drosophila  embryos during the establishment of the segmentation network, comparing wild-type and mutant embryos in which all graded maternal patterning inputs are eliminated. While during the period between zygotic genome activation and gastrulation many regions maintain stable accessibility, cis-regulatory modules (CRMs) within the network undergo extensive patterning-dependent changes in accessibility. A component of the network, Odd-paired ( opa ), is necessary for pioneering accessibility of late segmentation network CRMs.  opa- driven changes in accessibility are accompanied by equivalent changes in gene expression. Interfering with the timing of  opa  activity impacts the proper patterning of expression. These results indicate that dynamic systems for chromatin regulation directly impact the reading of embryonic patterning information.

Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network