Open AccessPossible Role of HER-2 in the Progression of Prostate Cancer from Primary Tumor to Androgen Independence
Author(s) -
Nigel P Murray,
Eduardo Reyes,
Cynthia Fuentealba,
Omar Jacob,
Nelson Orellana
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.15.6615
Subject(s) - prostate cancer , medicine , prostatectomy , pathological , androgen , prostate , blockade , cancer , oncology , tumor progression , endocrinology , hormone , receptor
The expression of HER-2 in prostate cancer has been linked to disease progression. We analysed the presence of HER-2 expression in primary tumors in men undergoing radical prostatectomy, its association with clinical and pathological findings, and its expression in secondary circulating prostate cells (CPCs) during follow up, as well as links with biochemical failure and the effects of androgen blockade.