Open AccessA Pilot Study of Perioperative External Circumferential Cryoablation of Human Renal Arteries for Sympathetic Denervation
Author(s) -
Claes Forssell,
Niclas Bjarnegård,
Fredrik Nyström
Publication year - 2020
Publication title -
vascular specialist international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 3
eISSN - 2288-7989
pISSN - 2288-7970
DOI - 10.5758/vsi.200023
Subject(s) - medicine , cryoablation , cryotherapy , denervation , blood pressure , renal artery , catheter , cryosurgery , sympathectomy , ambulatory , surgery , perioperative , anesthesia , cardiology , kidney , ablation
Cryoablation, which induces cellular death without extensive tissue damage, has been extensively used to denervate the myocardium. However, periadventitial external circumferential application of cryotherapy to denervate the renal artery sympathetic nerves has, to our knowledge, never been tested in humans. The main aim of this study was to examine the safety and potential effects of cryotherapy on ambulatory blood pressure levels and other outcomes that are indirectly related to sympathetic tone, including pulse-wave velocity, central pulse pressure, and glucose levels.