Open AccessIs there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
Author(s) -
Mehmet Okçu,
Fatmanur Aybala Koçak,
Samet Sancar Kaya,
Figen Tuncay
Publication year - 2021
Publication title -
turkish journal of physical medicine and rehabilitation :
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.235
H-Index - 5
ISSN - 2587-1250
DOI - 10.5606/tftrd.2021.5248
Subject(s) - bisphosphonate , osteoporosis , medicine , genetic predisposition , daughter , adverse effect , dentistry , biology , disease , evolutionary biology
Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data.