Open AccessComparative effects of fentanyl versus morphine on platelet inhibition induced by ticagrelor in patients with ST-segment elevation myocardial infarction: Full results of the PERSEUS randomized trial
Author(s) -
Juan F. Iglesias,
Marco Valgimigli,
Federico Carbone,
Nathalie Lauriers,
Pier Giorgio Masci,
Sophie Degrauwe
Publication year - 2022
Publication title -
cardiology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 33
eISSN - 1897-5593
pISSN - 1898-018X
DOI - 10.5603/cj.a2022.0049
Subject(s) - ticagrelor , medicine , fentanyl , morphine , conventional pci , percutaneous coronary intervention , myocardial infarction , pharmacodynamics , anesthesia , loading dose , cardiology , pharmacology , pharmacokinetics
Morphine reduces absorption and delays action onset of potent oral P2Y₁₂ receptor inhibitors in patients with ST-segment elevation myocardial infarction (STEMI). We sought to determine the differential effects of fentanyl compared to morphine on the pharmacodynamics and pharmacokinetics of ticagrelor in STEMI patients undergoing primary percutaneous coronary intervention (PCI).