Open AccessCardiac allograft vasculopathy in a long-term follow-up after heart transplantation: Role of remnant cholesterol in residual inflammation
Author(s) -
Emyal Alyaydin,
Christian Pogoda,
A. Dell 'Aquila,
Sven Martens,
Izabela Tuleta,
Holger Reinecke,
Juergen R. Sindermann
Publication year - 2022
Publication title -
cardiology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.573
H-Index - 33
eISSN - 1897-5593
pISSN - 1898-018X
DOI - 10.5603/cj.a2022.0013
Subject(s) - medicine , heart transplantation , cardiology , odds ratio , cardiac allograft vasculopathy , transplantation , inflammation , retrospective cohort study , confidence interval , proinflammatory cytokine , population , gastroenterology , environmental health
Cardiac allograft vasculopathy (CAV) is a major prognosis limiting factor in heart transplantation (HTx). Disease development and progression are influenced by multiple determinants, but the role of remnant cholesterol (RC) in CAV has not yet been investigated. Therefore, the present study aimed to assess the prevalence of CAV in a very long-term follow-up after orthotopic HTx and to examine the role of RC in residual inflammation despite secondary prevention.