Open AccessSimultaneous Effect of Organic Modifier and Physicochemical Parameters of Barbiturates on their Retention on a Narrow-Bore PGC Column. Part 2
Author(s) -
Tibor Cserháti,
M. Szögyi
Publication year - 2011
Publication title -
croatica chemica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.214
H-Index - 50
eISSN - 1334-417X
pISSN - 0011-1643
DOI - 10.5562/cca1639
Subject(s) - chemistry , column (typography) , chromatography , mathematics , connection (principal bundle) , geometry
The retention time of 23 barbituric acid derivatives was determined on an narrow-bore porous graphitized carbon (PGC) column employing water-dioxane mixtures as mobile phases. The retention fac-tor (k), theoretical plate number (N), and asymmetry factor (AF) were computed for each analyte in each mobile phase. Quantitative structure-retention relationship (QSRR) calculations using stepwise regression analysis (SRA) demonstrated the binding of analytes to the surface of PGC stationary phase is influenced by electrostatic interaction and sterical correspondence between the stationary phase and the various sub-structures of barbituric acid derivatives. (doi: 10.5562/cca1639