Open AccessAdvanced Paternal Age and Sperm DNA Fragmentation: A Systematic Review
Author(s) -
Daniel González,
Jesse Ory,
Rubén Blachman-Braun,
Sirpi Nackeeran,
Jordan C. Best
Publication year - 2022
Publication title -
the world journal of men's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.711
H-Index - 10
eISSN - 2287-4690
pISSN - 2287-4208
DOI - 10.5534/wjmh.200195
Subject(s) - dna fragmentation , male infertility , sperm , semen , infertility , andrology , gynecology , population , medicine , biology , genetics , pregnancy , apoptosis , environmental health , programmed cell death
Male ageing is often associated with defective sperm DNA remodeling mechanisms that result in poorly packaged chromatin and a decreased ability to repair DNA strand breaks. However, the impact of advanced paternal age on DNA fragmentation remains inconclusive. The aim of the present systematic review was to investigate the impact of advancing paternal age (APA) on DNA fragmentation.