Open AccessTestosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence
Author(s) -
Seon Mee Kang,
Hwa Jin Jung,
Min Jeong Kwon,
Soon Hee Lee,
Jeong Hyun Park
Publication year - 2021
Publication title -
the world journal of men's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.711
H-Index - 10
eISSN - 2287-4690
pISSN - 2287-4208
DOI - 10.5534/wjmh.200169
Subject(s) - senescence , apoptosis , testosterone (patch) , microbiology and biotechnology , endocrinology , biology , cancer research , medicine , chemistry , genetics
Androgens are steroid hormones that are very important in the sexual development and the maintenance of male reproductive system, and also have diverse actions in non-reproductive tissues, including potent antioxidant capacity. Type 2 diabetes mellitus is caused by tissue insulin resistance and insufficient insulin secretion from the pancreatic β-cells. The progressive decline of pancreatic β-cells in diabetes is closely related with the severity of disease. We wanted to know whether dihydrotestosterone (DHT) can protect insulin secreting pancreatic β-cells from apoptosis and accelerated senescence induced by oxidative stress.