Open AccessProtein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele
Author(s) -
Manesh Kumar Panner Selvam,
Ashok Agarwal,
Rakesh Sharma,
Luna Samanta,
Sajal Gupta,
Tânia R. Dias,
Ana D. Martins
Publication year - 2021
Publication title -
the world journal of men's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.711
H-Index - 10
eISSN - 2287-4690
pISSN - 2287-4208
DOI - 10.5534/wjmh.180108
Subject(s) - varicocele , semen , infertility , male infertility , andrology , exosome , downregulation and upregulation , sperm , blot , semen analysis , medicine , biology , microvesicles , microrna , pregnancy , genetics , gene
Aberrant expression of seminal plasma proteins are associated with altered homeostasis that may affect the fertilizing ability of spermatozoa. However, the precise roles of seminal exosomes on sperm function remain unclear. The objective of this study was to identify the differentially expressed proteins (DEPs) associated with varicocele-mediated infertility by comparing seminal plasma protein profile of unilateral varicocele patients with proven fertile donors.