Open AccessLiposoluble vitamins A and E in kidney disease
Author(s) -
Maria Helena Rojo-Trejo,
Ludivina RoblesOsorio,
Ernesto Sabath
Publication year - 2022
Publication title -
world journal of nephrology
Language(s) - English
Resource type - Journals
ISSN - 2220-6124
DOI - 10.5527/wjn.v11.i3.96
Subject(s) - medicine , oxidative stress , anorexia , kidney disease , disease , malabsorption , vitamin d and neurology , tocopherol , vitamin , dialysis , malnutrition , vitamin e , retinoic acid , kidney , physiology , endocrinology , antioxidant , biochemistry , biology , gene
Kidney disease (KD) is characterized by the presence of elevated oxidative stress, and this is postulated as contributing to the high cardiovascular morbidity and mortality in these individuals. Chronic KD (CKD) is related to high grade inflammatory condition and pro-oxidative state that aggravates the progression of the disease by damaging primary podocytes. Liposoluble vitamins (vitamin A and E) are potent dietary antioxidants that have also anti-inflammatory and antiapoptotic functions. Vitamin deficits in CKD patients are a common issue, and multiple causes are related to them: Anorexia, dietary restrictions, food cooking methods, dialysis losses, gastrointestinal malabsorption, etc. The potential benefit of retinoic acid (RA) and α-tocopherol have been described in animal models and in some human clinical trials. This review provides an overview of RA and α tocopherol in KD.