Open AccessCreatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old
Author(s) -
Carlos Guido Musso,
Joaquín Álvarez Gregori,
José Ricardo Jáuregui,
Juan F. Macías Núñez
Publication year - 2012
Publication title -
world journal of nephrology
Language(s) - English
Resource type - Journals
ISSN - 2220-6124
DOI - 10.5527/wjn.v1.i5.123
Subject(s) - uric acid , creatinine , endocrinology , medicine , reabsorption , renal function , renal physiology , furosemide , excretion , urea , loop of henle , kidney , aldosterone , sodium , chemistry , biochemistry , organic chemistry
RENAL PHYSIOLOGY IN THE HEALTHY OLDEST OLD HAS THE FOLLOWING CHARACTERISTICS, IN COMPARISON WITH THE RENAL PHYSIOLOGY IN THE YOUNG: a reduced creatinine clearance, tubular pattern of creatinine back-filtration, preserved proximal tubule sodium reabsorption and uric acid secretion, reduced sodium reabsorption in the thick ascending loop of Henle, reduced free water clearance, increased urea excretion, presence of medulla hypotonicity, reduced urinary dilution and concentration capabilities, and finally a reduced collecting tubules response to furosemide which expresses a reduced potassium excretion in this segment due to a sort of aldosterone resistance. All physiological changes of the aged kidney are the same in both genders.